S1-1 Opioid receptors: structure, function and plasticity

This presentation will review basic and clinical concepts on pain mechanisms underlying opioid analgesia. It describe the structure, function, cellular signaling of receptors; endogenous exogenous receptor ligands; as well central peripheral sites actions. The also discuss novel opioid-based therapeutic strategies, developed from recently gained knowledge structures signaling, pathological situations, in vivo studies, aimed at reduction side effects such respiratory depression, constipation, addiction, sedation tolerance. Lastly, problems associated with use be addressed.